Relatively chill T5 Gamma fit. A bit on the expensive side but only a few rooms actually require attention. In most cases burning to the gate and dropping the MTU works fine.

Drone Choice The Drone groups are: 1x Gecko + 1x Republic Fleet Valkyrie Launch two of those (one extra in case you need to cycle them due to drones taking heavy damage). Vs bigger targets, use both groups against the same target, vs smaller targets (frigate, destroyer, ephilates cruiser, scylla) use one group per target. The Reepublic Fleet Warrior is to be used to pop the cache and nodes. Afterwards it can be used as a bit of extra dps. Careful when using the warrior vs Karybdis Tyrannos as it might take heavy damage there.

Target Priority Priority are Neuts first, then Scrambling (scrambling might go after your drones which decreases their velocity substantially and will cost you precious seconds) and Webs as they will make it take longer for you to slowboat to the gate which offsets the time you have to tractor loot. Generally you want to burn to gate and drop MTU while having the warrior Drone to pop the cache and all nodes for the MTU to work it's magic while you fight off the enemies.

Run Time Time wise you should usually be around 13-17 minutes per run. Although having more than one Ephilates room makes these runs take longer.

Boosters & ADC The Boosters in the cargo hold should not be used for every run, they are there as a help if you encounter a particularly nasty room or to offset some piloting mistakes. Think of them as one of your two "OH-SHIT!" buttons. They might not always save your skin if you mess up but they have a good chance. The Assault damage control is for similar use.

Dangerous rooms

• Heavy neut rooms: The ishtar has a strong cap but if you encounter a lot of neuts (think 5+) it might be a good idea to kite them a bit until a few of them are dead instead of burning to the gate
• Harrowing Vedmaks: If you encounter more than 3 Vedmaks (especially harrowing ones) you will have to focus them down first as their damage will eventually be high enough to break your active tank
• Marshals: You should be able to deal with 3-4 Marshals at a time without much issue. If you encounter more than that, burn away with an overheated AB to minimize damage. If you fly through a blue cloud (signature radius increase), 3 Marshals will kill you, so avoid these like the plague for DED rooms. If you spawn inside one, you only have seconds to react. The first salvo always deals 0 damage but after that the boosters and the Assault Damage Control are all the buffer you have to get out of the cloud.
• Tessera (Drone Battlecruiser): These do a lot of damage within 15km and you will want to kite them for a bit until you reduced their numbers. Especially if you see Blastgrips (these to explosive damage which absolutely wrecks you in Gamma Abyssal Weather). Tessera deal a lot of damage vs drones due to being very close to them. If they attack your drones, you might have to recall [Shift+R) and send them out again to reset aggro.
• Blastgrip Tessela (Drone Frigates): Normally Drone Frigates aren't much of an issue. It is however not impossible to encounter rooms with 10+ Blastgrip ones. Do not underestimate these.

Edit 25th October 2021: Swapped to using Geckos+Valkyries